Posts Tagged disease

Primary Amyloidosis- Types, proteins and clinical associations

Type Deposited Protein Clinical Associations Systemic Immunoglobulin lambda chains Multiple myeloma Transthyretin Familial amyloidosis, senile cardiac amyloidosis Amyloidosis �€“ A protein Inflammation-associated amyloidosis Beta 2 -microglobulin Dialysis-related amyloidosis Immunoglobulin heavy chains Systemic amyloidosis Hereditary Fibrinogen alpha chain, Apo A1 and Apo A2 Familial systemic amyloidosis Lysozyme Familial systemic amyloidosis Central nervous system Beta protein precursor Alzheimer’s Prion protein Creutzfeldt-Jakob disease, Gerstmann-Strãussler-Scheinker disease, fatal familial insomnia Cystatin C hereditary cerebral hemorrhage with amyloidosis (Icelandic) Ocular Gelsolin Familial amyloidosis (Finnish) Lactoferrin Familial corneal amyloidosis Keratoepithelin Familial corneal dystrophies Localized Calcitonin Thyroid Carcinoma (Medullary) Amylin Insulinoma, type 2 diabetes Atrial natriuretic factor amyloid Isolated atrial amyloidosis Prolactin Pituitary amyloid Keratin Cutaneous amyloidosis Medin Aortic amyloidosis in elderly people

Complications of obesity

CVS – Hypertension, coronary artery disease, cor pulmonale, pulmonary hypertension of obesity, obesity related cardiomyopathy, atherosclerosis CNS – Stroke, Benign intracranial hypertension Neoplastic – Increased endometrial, prostate, gall bladder, breast and colon cancer Endocrine – Non Insulin Dependent Diabetes Mellitus(NIDDM), abnormal lipid profile GIT – cholecystitis, cholelithiasis, nonalcoholic steatohepatitis (NASH), fatty liver, gastro esophageal reflux disease(GERD) Pulmonary – Obstructive sleep apnea, Pickwickian syndrome(hypoventilation) Psychosocial -Depression, stigma, Orthopedic – Osteoarthritis, slipped capital femoral epiphyses, Blount and Legg-Calvé-Perthes disease, backache Gynecologic – Anovulation and infertility, hyperandrogenism and polycystic ovarian disease Obstetric – Pregnancy induced hypertension, large baby Surgical – Deep venous thrombosis, pulmonary embolism

Koilonychia – Spoon shaped nails

Koilonychia is relatively more frequent in children and usually resolves with aging. When in doubt the diagnosis can be confirmed by keeping a drop of water on the nail.

Alkaptonuria

Alkaptonuria is caused by inherited deficiency of the liver enzyme homogentisic aicd dioxygenase.

Clinical manifestations of Aspergillus infection of the lungs(Pulmonary aspergillosis)

There are four common manifestations of pulmonary aspergillosis namely – Allergic Broncho Pulmonary Aspergillosis (ABPA), Chronic Necrotizing Pulmonary Aspergillosis(CNPA), aspergilloma ('Fungal ball') and invasive aspergillosis.   1) ABPA - is almost exclusively seen in asthmatics or cystic fibrosis patients. It is basically an allergic reaction to aspergillus that is colonized in the airways

Syncope (Causes and Pathophysiology)

Syncope is defined as loss of consciousness due to decreased cerebral perfusion. Causes of syncope can be classified as Neuroregulatory, Arrhythmias and Hemodynamic.   A.

Download Free USMLE Step 1, Step 2, Step 3 Study Guides and Ebooks pdf

USMLE Medicine Ebook Download PDF This free ebook in pdf format contains valuable information on infectious diseases , rheumatology , pulmonary diseases , cardiology , endocrinology and metabolic diseases , gastroenterology , and nephrology. Download USMLE Medicine Overview Ebook Study Guide This free ebook in pdf format contains chapters in infectious diseases, rheumatology, pulmonary disease, cardiology, endocrinology and metabolic diseases, gastroenterology, and neurology.

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